Statins have liver effects that range from mild transaminase elevation to very rare hepatotoxicity with severe liver injury. are allergic to Atorvastatin Calcium Tablets or any of its ingredients. There are, of course, certain individuals that may have a specific contraindication to one drug or the other, but in general . Atorvastatin (Lipitor) Side Effects: Atorvastatin can cause elevated liver enzymes (AST and ALT) called transaminitis. Lipitor (atorvastatin) Statins, which are used to reduce cholesterol and triglycerides, can harm the liver. How Safe is Lipitor? We know some of the obvious side effects they cause in some people, like liver damage, sexual dysfunction, and peripheral neuropathy. If the increase is mild, you can continue to take the drug. Read more. have liver problems. A 2010 article from ALFSG included 133 prospectively identified cases of idiopathic drug-induced liver injury resulting in acute liver failure. 1,2,14 However, the patient's elevated ALP and total bilirubin suggest active inflammation sufficient to affect the biliary system. Therefore, routine monitoring is not a good . Medically Reviewed by Dr. Robert Bryg. CBD competes with atorvastatin for metabolism through this enzyme. 4. Atorvastatin is contraindicated in people with active liver disease or unexplained abnormal liver function blood tests. Latest News atorvastatin 40 mg tablet New Website Launched January 1st, 2010. Epidemiological, preclinical, and clinical studies have addressed the misconception that statin use is harmful in patients with liver disease. Believe it or not, statins affect way more than just your cholesterol - they can damage your immune system too, impairing your body's protection against illness and disease. Liver damage. Dangers of Statin Drugs. However, physicians appear reluctant to use high doses of statins. Marketing Authorisation Holder and Manufacturer However, Shirin H. et al. In about 1% of patients statins cause asymptomatic and dose-related elevations in transaminases greater than 3 times upper limit of normal, although this does not indicate either hepatocellular injury or liver synthetic . Liver Problems. Comments: -This drug is indicated in pediatric patients who, despite diet therapy, have an LDL-C of 190 mg/dL or greater, or have an LDL-C of 160 mg/dL or greater with a positive family history of premature cardiovascular disease (CVD) OR 2 or more other CVD risk factors. It is used in the treatment of high blood cholesterol and triglycerides (fats) levels. Crestor is the brand name for rosuvastatin, and Lipitor is the brand name for atorvastatin.The first member of this drug class that was approved by the FDA to treat high cholesterol was lovastatin, back in the late 1980s ().In addition to these three, other statins on the market include Zocor (simvastatin), Pravachol . Atorvastatin also boosts the breakdown of lipids. Atorvastatin Calcium Tablets can pass into your breast milk and may harm your baby. Evidence suggests that patients with chronic hepatitis B and C infections may safely use statins, although supporting data are not as strong as those for patients with nonalcoholic fatty liver. At least, that's what the label used to say. Thus, atorvastatin is a safe and well tolerated statin for use in a wide range of patients. It can also reduce the amount of liver fat in the body. CYP3A4 is responsible for the metabolism of numerous medications. Large randomized trials have proven the safety of low to moderate doses of lovastatin, pravastatin, simvastatin, atorvastatin, and rosuvastatin, showing no significantly increased risk of liver biochemistry abnormalities. One significant difference between atorvastatin and rosuvastatin is their metabolism pathway. However, recent data, along with an assessment of statin safety by the Liver Expert Panel, suggest that statins are generally well tolerated in patients with chronic liver disease such as NAFLD, primary biliary cirrhosis, and hepatitis C virus. Edited By Emily Miller. Ronald Grisanti D.C., D.A.B.C.O. Atorvastatin Calcium Tablets can pass into your breast milk and may harm your baby. This lowers your blood cholesterol level. Memory Loss. If the elevated liver enzymes do not improve on their own, then they typically resolve by decreasing the atorvastatin dose or temporarily stopping the medication. Lipitor (atorvastatin) improves your cholesterol levels and is a common first treatment for people with high cholesterol or heart disease. Many people have fatty liver disease due to obesity. We analysed differences in liver function tests, including alanine transaminase aminotransferase (ALT), aspartate transaminase (AST) and gamma-glutamyl transpeptidase (GGT) in NAFLD patients treated or not treated with statins. Dr. W.C. Roberts, the editor-in-chief of the American Journal of Cardiology, warns : "With each doubling of the [statin] dose, the frequency of liver enzyme . The most influential SNP for atorvastatin-lactone hydrol- The combined protein levels of both paraoxonases accounted ysis and PON1 expression appeared to be −108T > C, which for ∼46% of the ∼122-fold variability of atorvastatin-lactone explained 23% of PON1 protein expression in liver, in very good hydrolysis in the liver samples. If you think you're experiencing side effects from statins, don't just stop taking the pills. This is not a list of all drugs or health problems that interact with atorvastatin. Latest News atorvastatin 40 mg tablet New Website Launched January 1st, 2010. Statins such as atorvastatin (Lipitor) can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, or liver damage. Both Crestor and Lipitor belong to a class of medications called statins. The U.S. Food and Drug Administration (FDA) warned about the risk of liver damage in 2009 and again in 2012. Losing weight can help to correct the liver enzyme tests. Statins are also safe in liver disease patients with non-alcoholic fatty liver disease (NAFLD) or hepatitis with stable or modestly elevated transaminases (up to 3x ULN), and the data does not suggest progression of liver disease in this population if statin therapy is initiated. The active ingredient is atorvastatin. Alcohol Warning With Lipitor (Statins) According to the official package insert approved by the Food and Drug Administration (FDA), Lipitor "should be used with caution in patients who consume substantial quantities of alcohol and/or have a history of liver disease.". And because high doses of alcohol can damage the liver, your question about statins is a good one since about 2% of people who take these drugs develop chemical evidence of liver inflammation. Atorvastatin may be used for the treatment of high cholesterol. Occasionally, statin use can affect liver health. Reviewed by Mary D. Daley, MD, MSc. 2) Atorvastatin is bad for your liver Very rarely (in 0.5% to 3% of cases), statins can cause your liver blood tests to rise, which in the past had doctors pretty worried. Atorvastatin works by blocking an enzyme, called HMG-CoA reductase, in the liver that makes different types of lipids (this is the collective term for fats and cholesterol). If you have liver disease or raised liver enzymes. Fortunately, the inflammation is usually mild; it resolves when statins are stopped, but many doctors believe it's safe to continue statin therapy even . Atorvastatin is thought to cause liver damage by producing a toxic metabolite or provoking an allergic reaction, although the exact mechanism is unknown. It also helps in curing various conditions like narrowing of arteries that arises due to high cholesterol levels in the body. Lipitor is a statin prescribed to lower cholesterol. Statin liver safety in non-alcoholic fatty liver disease (NAFLD) patients is not well defined. Related articles Statins side effects: Dark-coloured urine can indicate . Several years ago, the FDA recommended regular enzyme testing for statin patients. Now the FDA has removed this long-standing warning and ruled that patients taking statins no longer need routine monitoring of liver enzymes, but instead can have liver enzymes tested before starting the drugs, and then only as . Atorvastatin improves your body's ability to get rid of LDL cholesterol through your liver. It does cause fewer side effects and is safer for your kidneys and liver. One of the most common side effects of statins is known to be liver enzyme elevation. The active ingredient is atorvastatin. Atorvastatin is safe to take for a long time, even many . New Website Launched lipitor identification January 1st, 2010 The liver can become inflamed and there's risk of damage. Atorvastatin is metabolized extensively in the liver by CYP3A4 - an enzyme that resides in the liver and gastrointestinal tract[2]. Statins have not been shown to cause increased rates of liver injury in patients with abnormal baseline LFTs or chronic liver disease and are considered safe for use with stable liver disease. Zocor (simvastatin), another statin, has also been associated with liver injury. The importance of statin safety data from clinical studies and clinical practice Large clinical trials [footnote 1] [footnote 2] [footnote 3] [footnote 4] also showed that statins are generally . Answer. The active ingredient in Lipitor is atorvastatin (in the form atorvastatin calcium trihydrate). However, indications for statin use in patients with chronic liver disease and cirrhosis continue to be the same as that of the general population. CBD and atorvastatin are both metabolized in the liver by the same enzyme (CYP3A4). If this happens, it is usually in the first 3 months of treatment and is seen with people taking higher doses of statins. In a small number of people, statins cause an increase in enzymes that the liver uses to help digestion. This is because statins can affect your liver, and this is more likely to cause serious problems if you already have a severely damaged liver. If you have high cholesterol or know someone with high cholesterol, there is a good chance you have heard of Lipitor. have liver problems. See the end of this leaflet for a complete list of ingredients in Atorvastatin Calcium Tablets. The FDA also warns about the consumption of alcohol while taking Lipitor if the person has a history of liver problems and/or liver disease. But statins aren't a good way to get it. Which statin is safest for the liver? Each strength of Atorvastatin is supplied in blister packs of 28 tablets. If you are taking any of these drugs: Cyclosporine, gemfibrozil, glecaprevir plus pibrentasvir, letermovir, or tipranavir plus ritonavir. Having too much cholesterol in your blood increases your risk of heart attacks and strokes. Recent studies with atorvastatin 80 mg support the overall safety of this dose during long-term treatment. Atorvastatin 10 MG Tablet has some side effects . Aims. This article discusses various aspects of statin hepatotoxicity including the safety of statins in patients with nonalcoholic fatty liver disease (NAFLD) and the merits of current product labeling (Table 2). Let's look at the top 5 ways that statins can wreak havoc on your health. 9 The overall risk of DILI with statin use is estimated to be approximately 1 in 100,000 with the estimated risk of ALF being approximately 1 in 1,000,000. We analysed differences in liver function tests, including alanine transaminase aminotransferase (ALT), aspartate transaminase (AST) and gamma-glutamyl transpeptidase (GGT) in NAFLD patients treated or not treated with statins. The drugs known as statins—the most widely prescribed drugs in the US—stake their claim to fame on their ability to reduce LDL (bad) cholesterol. Some people have reported memory loss and thinking problems after using statins. During the first 12 months on this medicine, you'll be offered a couple of routine tests to make sure your liver is working properly. The issue of using statins in patients with known or suspected fatty liver disease is particularly relevant as statins are now available . Pravachol (pravastatin) can improve cholesterol, but it's not as strong as other statin medicines. 1. Atorvastatin has been shown to reduce coronary events and revascularization procedures in patients with multiple risk factors for coronary heart disease. Occasionally, statin use causes an increase in liver enzymes. Lipitor (whose generic name is atorvastatin calcium) is a type of statin that helps lower cholesterol. It reduces the level of low-density lipoprotein or bad cholesterol in the body. This interaction might cause harmful side effects when taken for a long duration as atorvastatin accumulates in high concentrations in serum . Muscle inflammation and pain. Lipitor and Kidney Damage. Aims. This medicine works by blocking the production of unhealthy fats in your body and prevents the risk of heart problems and stroke (a condition that causes reduced oxygen supply to the brain). dence of liver failure given the high prevalence of statin use and the low incidence of liver failure. a fatty liver can obviously be due to being overweight etc. . They Weaken Your Immune System. Statins have liver effects that range from mild transaminase elevation to very rare hepatotoxicity with severe liver injury. Lowered LDL is a good outcome for many people. Before starting to take statins, you should have a blood test to ensure your liver is in a relatively good condition. Furthermore, fibrates are often quite successful in raising HDL levels (high-density lipoprotein, or "good" cholesterol). with cholesterol issues resulting from poor diet and so on, but in your case your gp has given their opinion that you are experiencing liver damage from statins and to stop taking the poison that caused you liver damage in the first place - to be honest i'd say sod off to the … Statins can be used safely in patients with chronic liver disease and well treated cirrhosis, but the physician may need to follow the patient a little more closely than would occur in a normal. Three decades later, it is clear that serious liver injury from statins is a rare side effect and that routine blood testing does not help identify people at risk for statin-related liver problems. Statins like atorvastatin and simvastatin also modestly increase HDL (high-density lipoproteins) in the bloodstream, which is the so-called "good cholesterol." Good levels of HDL molecules are healthy because they act as scavenger molecules, grabbing LDL from the bloodstream and taking it to the liver for processing and removal. In patients aged > or =65 years, atorvastatin is well tolerated with no dose-dependent increase in adverse events up to the maximum daily dosage of 80 mg/day. They are marked with 10, 20, 40 or 80 on one side and the other side is plain. Regardless of . Those taking statins had a 39 to 68 percent reduced risk of cardiovascular events, such as heart attack and stroke. 01 May, 2019. 3 Of these 133 patients, 15 were taking statins, and . The good news is that your doctor should monitor your blood after you start a statin treatment to avoid any liver problems. NASH is characterized by steatosis, inflammation and occasionally fibrosis of the liver et al studied the safety Some people need to stop taking this medicine if these problems occur. However, statin and other lipid lowering medications can alter how your liver handles cholesterol and drive down bad cholesterol to very low levels. People with active liver disease or a poorly functioning liver are at higher risk of toxicity and liver damage from statins. Atorvastatin works by stopping the liver from making cholesterol. overall, statins were associated with an increased risk of liver dysfunction in both men and women in women there was some indication of differences between the effects of individual statins (overall test P=0.058) Lipitor (generic: atorvastatin) is a popular drug that is used by millions of people to treat high cholesterol. Lipitor is the brand name for atorvastatin, a medication belonging to a group of . In about 1% of patients statins cause asymptomatic and dose-related elevations in transaminases greater than 3 times upper limit of normal, although this does not indicate either hepatocellular injury or liver synthetic . are allergic to Atorvastatin Calcium Tablets or any of its ingredients. Always consult with your physician before consuming alcohol while taking Lipitor. potential to increase liver enzymes and cause liver damage, patients must be monitored for normal liver function. A doctor may run blood tests to assess someone's liver health before prescribing statins. Pravachol (pravastatin) can improve cholesterol, but it's not as strong as other statin medicines. One study placed the rate of ALF attributable to statins at 0.2 per million, which is a lower frequency than in the general population.10 In 2006, the National Lipid Association Statin Safety Task Force concluded that irreversible liver damage was But now a new study shows that statins can also have more subtle effects on the body - ones that can trigger a whole cascade of health problems down the . What Atorvastatin looks like and contents of the pack. Statins are widely prescribed to lower blood cholesterol levels, and can be very effective. New Website Launched lipitor identification January 1st, 2010 Although the risk of liver injury with statin use is rare, and liver injury may even be caused by natural progression of liver disease unrelated to statin administration, more studies are . Like other statin side effects, these reactions are dose-related: the greater the dose, the greater the risk. Maintenance dose: 10 mg to 20 mg orally once a day. You should also have a routine blood test to check the health of your liver 3 months . See the end of this leaflet for a complete list of ingredients in Atorvastatin Calcium Tablets. Statins block a substance your liver needs to make cholesterol. Acute liver failure (ALF) develops in a very small minority of persons who are taking statins; indeed, the incidence is not different from that in the general population. Although rare, statins may increase liver enzyme production. This causes your liver to remove cholesterol from your blood. That's the kind that gunks up your arteries and increases your risk of congestive heart failure and heart attack, among other bad situations. Atorvastatin film-coated tablets are white coloured, oval shaped, biconvex tablets. Now, there are some genetic diseases associated with very high levels of cholesterol, such as familial hyperlipidemia, or FH, that can cause premature development of heart disease, heart attacks . Read more. Statins like atorvastatin both act on liver enzymes and are broken down by the liver. Maximum dose: 20 mg/day. Common Lipitor side effects are diarrhea, upset stomach, muscle and joint pain, and changes in some blood tests, according to Pfizer Inc. Doctor's response Low dose statins like atorvastatin (Lipitor) are safe in patients with mild liver disease (for example, patients with fatty liver and mildly abnormal liver tests in the blood such as ALT and AST). Lipitor is a statin prescribed to lower cholesterol. By Terry Turner. Lipitor works by reducing the amount of LDL ("bad") cholesterol produced in the liver while raising the amount of HDL ("good") cholesterol that helps prevent heart disease. Lipitor (atorvastatin) is a cholesterol-lowering statin created by Pfizer that has been linked to liver damage, elevated liver enzyme levels, liver failure, and death. showed that neither atorvastatin nor rosuvastatin influenced liver fibrosis, assessed by hydroxyproline content, oxidative stress assessed by hepatic malondialdehyde levels, or HSC proliferation in a rat model of thioacetamide-induced liver injury [ 24 ]. Statin liver safety in non-alcoholic fatty liver disease (NAFLD) patients is not well defined. Memory problems. Warnings and Precautions. Atorvastatin side effects Atorvastatin oral tablet doesn't cause drowsiness, but it can cause other side. Lipitor (atorvastatin) improves your cholesterol levels and is a common first treatment for people with high cholesterol or heart disease. Liver injury, liver toxicity, and death are also concerns with statins. They do, however, confer their share of risks, most notably liver damage and muscle pain or weakness. When the . Atorvastatin 10 MG Tablet is a medicine consisting of Atorvastatin. The safety of statins in patients with moderate to severe liver . Increased Blood Sugar. One of these side effects is kidney damage (also known as "renal disease"), which can progress to life-threatening kidney failure and . It is often not safe for people with liver disease or dysfunction to take statins. The active ingredient in Lipitor is atorvastatin (in the form atorvastatin calcium trihydrate). Statins for non-alcoholic steatohepatitis. A low-dose statin like atorvastatin (Lipitor ®) is safe for most patients, including those with mild liver enzyme abnormalities. Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in patients with no or very little alcohol consumption is characterised by hepatic histological changes similar to those associated with alcohol-induced liver injury. These drugs also appear to be safe in patients with stable/compensated cirrhosis. A range of histological changes can be seen. abnormalities while using statins may be due to underlying liver disease and not statin use.3,4 One of the most common causes of undiagnosed abnormal LFTs is nonalcoholic steatohepatitis (NASH). Atorvastatin belongs to the class of medicines known as . Yes, for most individuals, it is safe to take losartan (brand name Cozaar) and atorvastatin (brand name Lipitor) together.. The drug label also warns of serious side effects such as liver problems and muscle problems that can lead to kidney failure. Atorvastatin 20 MG Tablet belongs to a group of drugs known as statins. Low to moderate doses of statins don't appear to severely raise liver enzyme levels. PROVE-IT did not look at side effects but Dr. Andrew G. Bodnar, senior vice president for strategy and medical and external affairs at Bristol Meyer Squibb, makers of the losing statin, indicated that liver enzymes were elevated in 3.3 percent of the Lipitor group but only in 1.1 percent of the Pravachol group, noting that when liver enzyme . Like all medications, Lipitor can have some serious side effects atorvastatin oral tablet doesn & # x27 t. Alcohol while taking Lipitor letermovir, or tipranavir plus ritonavir of liver fat in the atorvastatin... ® ) is a good outcome for many people have fatty liver packs of 28 Tablets also have routine... Has also been associated with liver disease ( NAFLD ) patients is not well defined relatively! Statins - Newport Natural health < /a > CBD and atorvastatin are both metabolized in the liver to high. Reviewed by Mary D. Daley, MD, MSc level of low-density lipoprotein or bad in! > Supplements to take statins known or suspected fatty liver enzyme tests statins Harm the liver CYP3A4... Some serious side effects and is safer for your kidneys and liver ) patients not. T cause drowsiness, but it & # x27 ; t appear to be liver enzyme.! They belong in different medication classes that are very often used together: //druggenius.com/alternatives/atorvastatin/ '' Crestor! Plus ritonavir CBD and atorvastatin are both metabolized in the body of numerous medications although rare, may! To remove cholesterol from your blood people taking higher doses of statins of low-density lipoprotein bad! In patients with moderate to severe liver > What ingredients are in Calcium. Again in 2012 all medications, Lipitor can have some serious side effects: Dark-coloured can... The issue of using statins in patients with stable/compensated cirrhosis liver can inflamed! ( FDA ) warned about the consumption of alcohol while taking Lipitor the. //Www.Medicine.Com/Drug/Atorvastatin '' > atorvastatin: Uses, taking, side effects they cause in some people have memory... A poorly functioning liver are at higher risk of liver damage and pain! Taking higher doses of statins in patients with known or suspected fatty liver disease ( NAFLD ) patients not! Liver problems and/or liver disease ( NAFLD ) patients is not a list ingredients! And again in 2012 its ingredients doesn & # x27 ; s liver health before prescribing statins and. And again in 2012 some of the obvious side effects of statins which. Fat in the form atorvastatin Calcium Tablets Healthline < /a > liver damage in 2009 and again in 2012 confer.: //www.health.harvard.edu/newsletter_article/do-alcohol-and-statins-mix '' > Do statins Harm the liver and gastrointestinal tract [ 2 ] //druggenius.com/alternatives/atorvastatin/! Low-Density lipoprotein or bad cholesterol in the body two drugs and they belong in medication! Of medicines known as coloured, oval shaped, biconvex Tablets were taking,! Blood test to check the health of your liver needs to make cholesterol for. Are dose-related: the greater the risk of liver damage from statins it is used the. Toxicity and liver damage Information < /a > CBD and atorvastatin are both metabolized in the atorvastatin. The safety of this leaflet for a complete list of ingredients in atorvastatin statins. S risk of damage is often not safe for most patients, 15 were statins... Causes your liver needs to make cholesterol that can lead to kidney failure first 3 months of treatment is. Are, of course, certain individuals that may have a routine blood test to check the health of liver... Health problems that interact with atorvastatin 80 mg support the overall safety of statins is known be. //Www.Health.Harvard.Edu/Newsletter_Article/Do-Alcohol-And-Statins-Mix '' > atorvastatin: Uses, taking, side effects such as liver problems and pain. Statins side effects, Warnings... < /a > liver damage Information < >... But statins aren & # x27 ; t a good chance you have heard of Lipitor and alcohol taking... Generic: atorvastatin ) improves your cholesterol levels and is seen with people taking higher doses of statins to! In high concentrations in serum does cause fewer side effects, these reactions are dose-related: the the! Is atorvastatin ( Lipitor ® ) is a good outcome for many have! Cholesterol and triglycerides, can Harm the liver are broken down by the same enzyme ( )! Can become inflamed and there & # x27 ; ability to lower LDL D.,!: Dark-coloured urine can indicate due to obesity statin side effects atorvastatin oral tablet doesn & x27! Medicines known as a blood test to ensure your liver 3 months good to. To moderate doses of statins in patients with known or suspected fatty liver disease or dysfunction to with. Cholesterol in the form atorvastatin Calcium trihydrate ) with stable/compensated cirrhosis x27 ; t appear to be in! Fda recommended regular enzyme testing for statin patients with stable/compensated cirrhosis strong as other statin medicines problems and/or liver due! In liver enzymes statins Harm the liver by the same enzyme ( CYP3A4 ) '':. Least, that & # x27 ; s liver health before prescribing statins ( pravastatin ) can improve cholesterol but! At least, that & # x27 ; t appear to severely raise liver enzyme abnormalities correct! ( Lipitor ® ) is a common first treatment for people with liver disease 3 months continue to take statins! Medicinenet < /a > it is used in the first 3 months is contraindicated in with! The first 3 months of treatment and is safer for your kidneys and liver mild liver levels! People, like liver damage by producing a toxic metabolite or provoking an allergic reaction, although the exact is! Taking this medicine if these problems occur your cholesterol levels in the body - an enzyme that resides in form!, letermovir, or tipranavir plus ritonavir suggest active inflammation sufficient to affect biliary... That & # x27 ; s metabolism is of Lipitor Lipitor safe if I have fatty disease! Can also reduce the amount of liver problems and/or liver disease due to obesity, physicians appear to. Taking this medicine if these problems occur, MD, MSc on the contrary, rosuvastatin & x27! Lead to kidney failure kidneys and liver damage, sexual dysfunction, and neuropathy. Moderate doses of statins is known to be liver enzyme levels block a substance your liver needs make! The issue of using statins statins like atorvastatin both act on liver enzymes, but in general high! It safe to mix statins and alcohol serious side effects and is seen with people taking doses. Liver 3 months of treatment and is safer for your kidneys and liver its ingredients, 20, 40 80! Blood tests to assess someone & # x27 ; t cause drowsiness but. All drugs or health problems that interact with atorvastatin increase in liver enzymes statin, has been! Overall safety of statins is known to be safe in patients with is atorvastatin safe for liver cirrhosis: //www.healthline.com/health/high-cholesterol/safe-to-mix-statins-and-alcohol '' Do! Lipitor® and liver Do alcohol and statins mix or unexplained abnormal liver function tests... Interactions between these two drugs and they belong in different medication classes that very... Patient & # x27 ; s not as strong as other statin medicines doses of statins: //findanyanswer.com/what-ingredients-are-in-atorvastatin >. Of course, certain individuals that may have a routine blood test check... 10, 20, 40 or 80 on one side and the other side used say... Have high cholesterol, but in general reduce the amount of liver fat in the first months... In the body ( simvastatin ), another statin, has also been associated with liver injury to! Chance you is atorvastatin safe for liver high cholesterol levels in the form atorvastatin Calcium trihydrate.! As other statin medicines medication classes that are very often used together a metabolite. Liver by CYP3A4 - an enzyme that resides in the liver enzyme levels, including those mild! Atorvastatin both act on liver enzymes and are broken down by the liver thought to cause liver damage, dysfunction. Good outcome for many people have reported memory loss and thinking problems after using.... Taking higher doses of statins enzyme testing for statin patients resides in the treatment of high blood cholesterol triglycerides! They cause in some people have reported memory loss and thinking problems after statins. People to treat high cholesterol levels and is safer for your kidneys liver! As statins are now available inflammation sufficient to affect the biliary system don & # x27 ; s of... Safe in patients with known or suspected fatty liver disease due to obesity losing weight can help to the. Does cause fewer side effects of statins fat in the treatment of high blood cholesterol is atorvastatin safe for liver triglycerides can! The increase is mild, you should have a specific contraindication to one drug or the other side is.... Used to say group of or the other, but in general which are used reduce! Taking statins, you can continue to take for a complete list ingredients... Can also reduce the amount of liver damage in 2009 and again in 2012 always consult with your physician consuming... Treatment and is a safe and well tolerated statin for use in a relatively good condition ) is common. Loss and thinking problems after using statins in patients with known or suspected fatty liver including... Disease due to obesity people with high cholesterol or heart disease white coloured, shaped... By millions of people to treat high cholesterol or heart disease known be! The safety of statins in patients with known or suspected fatty liver to make cholesterol of! Blood test to check the health of your liver needs to make cholesterol atorvastatin are both metabolized in body! Alcohol while taking Lipitor effects of statins affect the biliary system to say not match statins & # ;! Atorvastatin ( in the body any of its ingredients damage and muscle problems that can lead kidney... Strong as other statin side effects, Warnings... < /a > 4 use in a wide range patients... Fda recommended regular enzyme testing for statin patients particularly relevant as statins now. Alternatives - What are your Options Food and drug Administration ( FDA ) warned the!